The Colts (4-6-1) dropped their first game under interim head coach Jeff Saturday against the NFL-best Philadelphia Eagles. Despite the loss, the Colts showed fight and renewed tenacity. It has been the identity of the team since Saturday took over at the helm.
The Steelers are 1-4 on the road this season. Rookie quarterback Kenny Pickett continues to progress but gets a tough challenge against a Colts defense that ranks 11th overall in points allowed.
Here's a look at the betting details and USA TODAY's NFL staff picks for the Steelers vs. Colts Week 12 game:
Steelers at Colts odds, moneyline and over/under
Spread: Colts (-2.5)
Moneyline: Colts (-140); Steelers (+120)
More odds, injury info for Steelers vs. Colts
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NFL Week 12 odds, predictions and picks
Bills at Lions | Giants at Cowboys | Patriots at Vikings | Broncos at Panthers | Buccaneers at Browns | Ravens at Jaguars | Texans at Dolphins | Bears at Jets | Bengals at Titans | Falcons at Commanders | Chargers at Cardinals | Raiders at Seahawks | Rams at Chiefs | Saints at 49ers | Packers at Eagles | Steelers at Colts
Lorenzo Reyes: Steelers 24, Colts 21
I'm still not sold on the Jeff Saturday Colts, despite their playing with more intensity and efficiency since Frank Reich got fired. As long as Pittsburgh can generate a pass rush, it should generate turnovers. That will be the key to the upset.
Safid Deen: Steelers 23, Colts 17
This has all the makings of a matchup between top running backs like Colts star Jonathan Taylor and Steelers starter Najee Harris. But Steelers edge rusher and reigning defensive player of the year J.J. Watt will have the biggest impact on this game.
Lance Pugmire: Colts 21, Steelers 17
Expect the defense to carry this Monday night affair - the total is 39.5 - with Jonathan Taylor controlling the clock and providing the difference.
Jarrett Bell: Steelers 27, Colts 23
Nate Davis: Colts 24, Steelers 20
Tyler Dragon: Colts 24, Steelers 17
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Interior defensive linemen
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This article originally appeared on USA TODAY: Pittsburgh Steelers at Indianapolis Colts: Game predictions, picks, odds