Staying at home after a short week on the heels of Monday Night Football, Barkley, Daniel Jones and the Giants face a tough test in a hard-running Bears team. Will Fields, Khalil Herbert and the Bears be too much for New York to handle? Or will the Giants find a way to win? The game is set to kick off Sunday at 1 p.m. from MetLife Stadium.
Here's a look at the betting details and USA TODAY's NFL staff picks for the Bears vs. Giants Week 4 game:
Bears at Giants odds, moneyline and over/under
Spread: Giants (-2.5)
Moneyline: Giants (-150); Bears (+125)
More odds, injury info for Bears vs. Giants
VETERAN QBs ON NEW TEAMS: How seven have performed entering Week 4
WHAT TO WATCH: Super Bowl 55 rematch Sunday; Rams clash with 49ers Monday night
OPENINGS & BARRIERS: The NFL coaches project
NFL Week 4 odds, predictions and picks
Dolphins vs. Bengals | Vikings vs. Saints | Browns vs. Falcons | Seahawks vs. Lions | Jaguars vs. Eagles | Commanders vs. Cowboys | Titans vs. Colts | Jets vs. Steelers | Bills vs. Ravens | Chargers vs. Texans | Bears vs. Giants | Cardinals vs. Panthers | Patriots vs. Packers
Lorenzo Reyes: Giants 20, Bears 14
Daniel Jones was under constant duress Monday night and he should have more time to operate. But Saquon Barkley is the key here. He looks to have regained his rookie year form and the Bears struggle to stop the run. I like the Giants to cover but, honestly, the safest play here is probably the under.
Safid Deen: Bears 20, Giants 17
The Bears are 2-1, but somehow their second-year starter has this crazy stat to his name: Justin Fields' 297 yards passing through three games is the lowest for a quarterback since 1975. On the other side, Daniel Jones is also 2-1 but hasn't eclipsed 200 yards in any of his three starts either. The Giants suffered their first loss last week to backup Cooper Rush and the Cowboys and looked more like the team we expected them to be despite their 2-0 start. If the Bears open it up and let Fields cook, Chicago will improve to 3-1 this week.
Lance Pugmire: Bears 20, Giants 17
The week's lowest total (39.5) portends a defensive battle, and it's best to lean on Justin Fields making the defining play to decide this ancient rivalry.
Jarrett Bell: Giants 23, Bears 16
Nate Davis: Giants 22, Bears 16
Tyler Dragon: Giants 20, Bears 16
WEEK 4 POWER RANKINGS: Who takes over No. 1 spot after losses by Bills, Chiefs?
32 THINGS WE LEARNED FROM WEEK 3: Super Bowl, MVP favorites emerging?
SALUTE: Bears RB Khalil Herbert dedicates Week 3 performance to David Montgomery
NFL salaries: These are the highest-paid NFL players
Interior defensive linemen
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This article originally appeared on USA TODAY: Chicago Bears at New York Giants: Game odds, picks, predictions