Arizona Cardinals at Carolina Panthers: Predictions, picks and odds for NFL Week 4 matchup




Despite high expectations coming into the year, Kyler Murray and the Arizona Cardinals are just 1-2 on the 2022 NFL regular this season and looking to get back on the winning track when they travel to Carolina to face Baker Mayfield's Panthers.

Mayfield, Christian McCaffrey and the Panthers are favored at home against a struggling Kliff Kingsbury-coached Cardinals squad. Can Arizona get itself back in the NFC West race? Or will the Panthers get their second win of the year? The game is scheduled to kick off at 4:05 p.m. from Bank of America Stadium.

Here's a look at the betting details and USA TODAY's NFL staff picks for the Cardinals vs. Panthers Week 4 game:

Cardinals at Panthers odds, moneyline and over/under

  • Spread: Panthers (-0.5)

  • Moneyline: Panthers (-112); Cardinals (+10)

  • Over/under: 43.5

  • More odds, injury info for Cardinals vs. Panthers

NEW QBs ON NEW TEAMS: How seven have performed entering Week 4

WHAT TO WATCH: Super Bowl 55 rematch Sunday; Rams clash with 49ers Monday night

OPENINGS AND BARRIERS: The NFL coaches project

NFL Week 4 odds, predictions and picks

Dolphins vs. Bengals | Vikings vs. Saints | Browns vs. Falcons | Seahawks vs. Lions | Jaguars vs. Eagles | Commanders vs. Cowboys | Titans vs. Colts | Jets vs. Steelers | Bills vs. Ravens | Chargers vs. Texans | Bears vs. Giants | Cardinals vs. Panthers | Patriots vs. Packers

Lorenzo Reyes: Cardinals 21, Panthers 18

Was that a get-right game for Carolina, or just an aberration? Given that the Panthers hadn't covered any of their previous nine games before last week's win against the Saints, I'm going to hold off on backing them until I see more. And the Cardinals should be feeling enough pressure to play with more urgency and efficiency.

Sep 25, 2022; Glendale, AZ, USA; Arizona Cardinals quarterback Kyler Murray scrambles out of the pocket against the Los Angeles Rams at State Farm Stadium.
Sep 25, 2022; Glendale, AZ, USA; Arizona Cardinals quarterback Kyler Murray scrambles out of the pocket against the Los Angeles Rams at State Farm Stadium.  

Safid Deen: Cardinals 24, Panthers 16

Can the Carolina Panthers pull off two straight wins? They got a much-needed win last week against the Saints, breaking a nine-game losing skid dating back to last season and providing some relief for coach Matt Rhule's hot seat. The Panthers depended on a feisty defense, which intercepted Jameis Winston twice and returned a fumble for a touchdown. But the challenge will be much tougher with Kyler Murray and the Cardinals coming to town this week. The 4 p.m. ET start also favors Arizona. Give me the Cardinals in this one.

Lance Pugmire: Cardinals 24, Panthers 20

The back-to-back Heisman Trophy winners from Oklahoma - Kyler Murray and Baker Mayfield - have also shared hometown scorn from their NFL fans, and Murray needs this one most to win over the herd currently making him the target of their disappointment.

Jarrett Bell: Cardinals 26, Panthers 24

Nate Davis: Cardinals 25, Panthers 17

Tyler Dragon: Cardinals 23, Panthers 20

WEEK 4 POWER RANKINGS: Who takes over No. 1 spot after losses by Bills, Chiefs?

32 THINGS WE LEARNED FROM WEEK 3: Super Bowl, MVP favorites emerging?

LONG GAME: Panthers owner David Tepper to remain patient with head coach Matt Rhule

NFL salaries: These are the highest-paid NFL players

  • All players

  • Quarterback

  • Running back

  • Wide receiver

  • Tight end

  • Tackle

  • Guard

  • Center

  • Kickers

  • Edge rusher

  • Safety

  • Cornerback

  • Linebacker

  • Interior defensive linemen

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This article originally appeared on USA TODAY: Arizona Cardinals at Carolina Panthers: Game odds, picks, predictions

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