It was George's highest points total since joining the Thunder in an offseason trade. He made 13 of 22 shots and had nine rebounds and seven assists.
The Thunder led 63-55 at halftime behind 21 points by George and 17 by Westbrook. The Clippers shot 54 percent before the break, but they turned it over 11 times and were outscored 17-12 at the free throw line.
The Thunder continued their surge early in the third quarter. A 3-pointer by Anthony pushed Oklahoma City ahead by 15. The Thunder increased their lead to 20 before the Clippers chipped away late in the quarter to cut their deficit to 94-86 at the end of the period. A 3-pointer by Austin Rivers tied it at 105 midway through the fourth.
The Thunder held the Clippers to one field goal in the final three minutes.