Chiefs receiver Tyreek Hill was carted off in the first quarter with a shoulder injury.
Kansas City lists him as questionable to return.
Hill had two catches for 16 yards before departing.
He was injured on his second catch, which went for 8 yards. Jaguars cornerback Jalen Ramsey tackled Hill, who immediately reacted as if he were in pain.
The Chiefs have done just fine without him so far, leading 17-7 after the first quarter.
LeSean McCoy has two carries for 15 yards.