It was the third time in franchise history - dating to their days as the Washington Senators - and second time this season Minnesota homered eight times. Before doing it April 20 against Baltimore, the last time it happened was in 1963 against Washington.
Schoop drove in four runs and Sano three as the Twins won six of seven on their road trip that began in Seattle and wound up with their first sweep in Anaheim since 1996. Minnesota, with the best record in the majors, hit 22 homers against the Mariners and the Angels while outscoring them 67-24.
There were a total of 11 home runs in this game, which was originally set for Wednesday but postponed due to unplayable field conditions following a pregame storm.
Angels first baseman Jared Walsh, who made five relief appearances in Triple-A this season, pitched for the first time in the majors. He gave up a run on two hits and a walk in the ninth.
The eight home runs also tied the Angels mark for most allowed. It previously happened in 2005 against Texas and 1996 vs. Oakland.
Four of the seven hits Matt Harvey (2-4) allowed in 2 2/3 innings went over the wall as the right-hander gave up eight runs for the second time this season.
Minnesota broke open the game in the second inning with six runs, which included a three-run shot by Schoop and two-run drive by Polanco. Harvey was chased in the third after solo homers by Cron and Sano.
The Twins hit three home runs in the seventh to extend their lead to 14-2. Sano's two-run shot and Schoop's solo homer marked the sixth time the Twins had gone back-to-back this season. Kepler added a two-run drive.
Twins starter Martin Perez (7-1) went five innings and yielded two runs on five hits.
Angels right fielder Kole Calhoun came up twice with the bases loaded but was unable to get a hit. He struck out in the third and grounded into a force out to end the fifth.
Twins: DH Nelson Cruz (left wrist sprain) returned to Minneapolis. He is eligible to come off the injured list on Friday but manager Rocco Baldelli said they are still seeing how he is doing swinging during batting practice.
Angels: SS Andrelton Simmons (left ankle sprain) saw a foot and ankle specialist Wednesday and expects to remain in a walking boot for at least two weeks. . LHP Andrew Heaney (elbow) had a bullpen session before Thursday's game and could make his season debut Sunday.
Twins: Return home and open a three-game series against the Chicago White Sox. RHP Jose Berrios (6-2, 3.39 ERA) has seven or more strikeouts in his last four starts.
Angels: Conclude their home stand with three games against Texas. RHP Griffin Canning (2-3, 3.80 ERA), who became the second LA starter to go seven innings last Saturday against Kansas City, gets the call on Friday.
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