New Orleans Saints at San Francisco 49ers: Predictions, picks and odds for NFL Week 12 matchup




The San Francisco 49ers (6-4) have hit their stride this season. The addition of star running back Christian McCaffrey has transformed the 49ers' offense and made it more explosive.

McCaffrey is still working his way into the game plan, but he has given quarterback Jimmy Garoppolo a safety valve from the pocket. The Saints (4-7) know McCaffrey well and will look to neutralize his activity on Sunday.

The Saints have lost three of their last five games. They will look to get back on track against the 49ers' defense which features star edge-rusher Nick Bosa and linebacker Fred Warner.

Here's a look at the betting details and USA TODAY's NFL staff picks for the Saints vs. 49ers Week 11 game:

Saints at 49ers odds, moneyline and over/under

  • Spread: 49ers (-8.5)

  • Moneyline: 49ers (-425); Saints (+350)

  • Over/under: 43

  • More odds, injury info for Saints vs 49ers

CONTENDERS: 49ers looking like contender following blowout vs. Cardinals 

WEEK 12 NFL POWER RANKINGS: Cowboys jump into top 5, Vikings tumble six spots

COACHES PROJECT: Evaluating how nepotism stunts NFL coaching diversity

NFL Week 12 odds, predictions and picks

Bills at Lions | Giants at Cowboys | Patriots at Vikings | Broncos at Panthers | Buccaneers at Browns | Ravens at Jaguars | Texans at Dolphins | Bears at Jets | Bengals at Titans | Falcons at Commanders | Chargers at Cardinals | Raiders at Seahawks | Rams at Chiefs | Saints at 49ers | Packers at Eagles | Steelers at Colts

Lorenzo Reyes: 49ers 27, Saints 20

Andy Dalton played well enough to save his job and keep the Saints' season afloat. This Niners defense, however, is a far tougher test. And with San Francisco at full health and Jimmy Garoppolo minimizing mistakes, it should be a comfortable victory.

Aug 26, 2022; New Orleans, Louisiana, USA; New Orleans Saints wide receiver Chris Olave (12) looks on during warmups before the game against the Los Angeles Chargers at Caesars Superdome.
Aug 26, 2022; New Orleans, Louisiana, USA; New Orleans Saints wide receiver Chris Olave (12) looks on during warmups before the game against the Los Angeles Chargers at Caesars Superdome.  

Safid Deen: 49ers 31, Saints 17

The 49ers have the first of three straight home games, with a chance to lock up the No. 1 seed in the NFC playoff race this season if they really commit to being the team they looked like when they beat the Cardinals in Mexico. I like San Francisco to beat New Orleans this week.

Lance Pugmire: 49ers 30, Saints 14

As the Dolphins, Buccaneers and seahawks await, San Francisco grasps the urgency and wins convincingly against Andy Dalton and a team that's 1-3 on the road.

Jarrett Bell: 49ers 31, Saints 20

Nate Davis: 49ers 29, Saints 20

Tyler Dragon: 49ers 26, Saints 1

NFL PLAYOFF PICTURE: Which middling NFL teams are going to get hot and reach the playoffs?

HALL OF FAME: Darrelle Revis, Joe Thomas among Class of 2023 Pro Football Hall of Fame semifinalists

RELATED: Which offseason move has paid off the most for its respective NFL team?

NFL salaries: These are the highest-paid NFL players

  • All players

  • Quarterback

  • Running back

  • Wide receiver

  • Tight end

  • Tackle

  • Guard

  • Center

  • Kickers

  • Edge rusher

  • Safety

  • Cornerback

  • Linebacker

  • Interior defensive linemen

Gannett may earn revenue from sports betting operators for audience referrals to betting services. Sports betting operators have no influence over nor are any such revenues in any way dependent on or linked to the newsrooms or news coverage. See applicable operator site for its terms and conditions. If you or someone you know has a gambling problem, help is available. Call the National Council on Problem Gambling 24/7 at 1-800-GAMBLER. Must be 21 or older to gamble.

This article originally appeared on USA TODAY: New Orleans Saints at San Francisco 49ers: Game predictions, picks, odds

COMMENTS

More Related News

Joe Montana: If Brock Purdy is healthy I think it
Joe Montana: If Brock Purdy is healthy I think it's his job, Trey Lance isn't ready

The quarterback who won four Super Bowls with the 49ers has had no hesitation about speaking his mind on the 49ers' current quarterback situation, and he doesn't think Trey Lance is ready to lead a team to a Super Bowl. Joe Montana appeared today on PFT Live and said that his previous comments about the [more]

Roger Goodell speaks at Super Bowl 57: On Damar Hamlin, Commanders, concussions and more
Roger Goodell speaks at Super Bowl 57: On Damar Hamlin, Commanders, concussions and more

NFL commissioner Roger Goodell, speaking at Wednesday news conference before the Super Bowl, said the game of football "has never been better."

Everything you need to know about the NFL Experience - music, schedule, ticket prices
Everything you need to know about the NFL Experience - music, schedule, ticket prices

The NFL Experience will feature live music from Jimmy Eat World and Lee Brice as well as a Super Bowl watch party. The event starts Thursday in downtown Phoenix, heres how much it costs and how many days it will run.

Full list of 2023 NFL draft prospects invited to combine
Full list of 2023 NFL draft prospects invited to combine

Here is the full list of prospect invites for the 2023 NFL combine.

Pinterest: Q4 Earnings Snapshot
Pinterest: Q4 Earnings Snapshot
  • US
  • 2023-02-06 21:40:17Z

Pinterest: Q4 Earnings Snapshot

Leave a Comment

Your email address will not be published. Required fields are marked with *

Cancel reply

Comments

Top News: Football