Ildemaro Vargas drove in two runs and scored twice for Arizona. Adam Jones had two hits, and Kevin Cron added a double and two RBIs in his major league debut.
The Diamondbacks have outscored the Giants 28-6 in the first two games of this series.
One day after setting a season-high with 21 hits, Arizona had another big day at the plate with 13 hits. Every starter except pitcher Taylor Clarke had at least one, and six players drove in runs.
Clarke (1-1) pitched into the seventh and allowed three runs for his first career win. The right-hander struck out four and walked three in his second career start after being called up from Triple-A Reno before the game.
Pablo Sandoval singled in a pair of runs for San Francisco. Mike Yastrzemski, the grandson of Hall of Famer Carl Yastrzemski, went 0-for-3 with two strikeouts and scored a run in his major league debut with the Giants.
Marte tripled and scored leading off the game before homering off starter Andrew Suarez (0-2) leading off the third.
Leading 6-1, the Diamondbacks scored four in the fifth to pull away. Cron and Tim Locastro had RBI-doubles and two more scored when Alex Avila's sharp grounder rolled under the glove of first baseman Brandon Belt for an error.
Arizona benefited from an overturned call in the first after San Francisco right fielder Kevin Pillar made a spectacular diving catch to rob Cron of a one-out hit. Pillar got up and threw to first base to double up Jones just as Vargas scored. Umpire Mark Ripperger initially ruled that the third out was made before Vargas crossed home. Arizona manager Torey Lovullo asked for a review and the call was changed.
The Diamondbacks made their own defensive gem in the sixth. Right fielder Blake Swihart bobbled Pillar's double but made a strong throw to third baseman Eduardo Escobar, who came off the bag and tagged a sliding Pillar well short of the base.
Suarez allowed nine runs in four innings. Suarez also collected his first RBI with an infield single in the second.
Giants: Reliever Trevor Gott was placed on the 10-day injured list with a right forearm strain.
Diamondbacks RHP Luke Weaver (3-3, 3.14 ERA) pitches Sunday and has 55 strikeouts over his last eight starts. Weaver has two wins in three career starts against San Francisco. RHP Shaun Anderson (0-0, 3.60) takes the mound for the Giants.
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